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Wu, J., Meng, Z., Jiang, Min., Zhang, E., Trippler, M., Broering, R., Bucchi, A., Krux, F., Dittmer, U., Yang, D., Roggendorf, M., Gerken, G., Lu, M., and Schlaak, J. F. (2010) TLR-induced innate immune responses in non-parenchymal liver cells are cell type-specific. Immunology 129: 363374. 2. Wu, C. C., Zhang, X. Y., Tian, Y. J., Song, J. H., Yang, D. L., Roggendorf, M., Lu, M., and Chen, X. W. (2010) The biological significance of amino acid substitutions in hepatitis B surface antigen for the glycosylation, secretion, antigenicity and immunogenicity of HBsAg and assembly and replication of HBV. J Gen. Virol, 91:483-92. (Corresponding author). 3. Zhu, W. B., Chang, Y. Z., Wu, C., Han, Q., Pei, R. J., Lu., M., and Chen, X. (2010) Wild type hepatitis C virus core protein inhibits the initiation of antigen-specific T- and B-cell immune responses. Clin. Vacc. Immunol. 17(7):1139-47. (Corresponding author) 4. Bring, M., Zhang X., Kottilil, S., Trippler, M., Jiang, M., Lu, M., Gerken, G., and Schlaak, J.F. (2010) The interferon stimulated gene 15 is a provial factor for the hepatitis C virus and an attenuator of the IFN response. Gut: 9(8):1111-9. 5. Roggendorf, M., Yang, D., and Lu, M. (2010) The woodchuck: a model for therapeutic vaccination against hepadnaviral infection. Pathologie Biologie 58(4):308-14. (invited Reivew). 6. Kosinska, A., Zhang, E., Lu, M., and Roggendorf, M. (2010) Therapeutic vaccination in chronic hepatitis B: preclinical studies in the woodchuck. Hepatitis Research and Treatment: Volume 2010, Article ID 817580 (Review). 7. Shen, Q. L., Cicinnati, V. R., Zhang, X., Iacob, S., Weber, F., Sotiropoulos, G. C., Radtke, A., Lu. M., Paul, A., Gerken, G., Beckebaum, S. (2010) Role of microRNA-199a-5p and discoidin domain receptor 1 in human hepatocellular carcinoma invasion. Mol Cancer 9: 227, online. 8. Li, Y.M., Chen, J., Wu, C., Wang, L., Lu, M., Chen, X. (2010) HBV/HCV up-regulates Angiopoietin-2 Expression via MAPKs pathway. Hepatol. Res. 40:1022-33. 9. Wang, B., Tian, Y., Meng, Z., Min, J., Wei, B-.-Q., Tao, Y.-Q., Fan, W., Li, A., Bao, J., Li, X., Zhang, Z., Wang, Z.-D., Wang, H., Roggendorf, M., Lu, M., and Yang, D.-L. (2011) Establishing a new animal model for hepadnaviral infection: Susceptibility of Chinese Marmota-species to woodchuck hepatitis virus infection. J Gen Virol, 92:681-91 (corresponding author) 10. Zhang, X., Ma, Z., Zhang, E., Pei, R., Jiang, M., Schlaak, J. F., Roggendorf, M., and Lu M. (2011) Modulation of HBV Replication and Hepatocyte Differentiation by MicroRNA-1. Hepatology: 53(5):1476-85. 11. Zhang, Z. H., Li, L., Zhao, X. P., Glebe, D., Leistner, C., Zhang, Z. M., Wang, B. J., Yang, Y., Gerlich, W., Roggendorf, M., Li, X., Lu, M., and Yang, D. L. (2011) Elimination of hepatitis B virus surface antigen and appearance of neutralizing antibodies in chronically infected patients without virus clearance. J. Viral. Hepat.: 18, 424433. (Corresponding author) 12. Wang, B., Bao, J. J., Jiang, M., Wang, Y., Xing, M. Y., Zhang, W. G., Qi, J. Y., Roggendorf, M., Lu, M., and Yang, D. L. (2011) The expression of programmed death 1 (PD-1) and its ligands in Liver Tissues of Patients with Hepatitis and Hepatocellular Carcinoma.World J. Gastroenterol.: in press. 13. Broering ,R., Lu, M., and Schlaak, J. F. Toll/like receptor in liver health and disease> mechanisms and therapeutic potential. Clin. Sci. in press. 14. Xu, Y., Kck, J., Lu, Y., Yang, D., Lu, M., and Zhao, X. Tumor necrosis factor alpha of Tupaia belangeri is able to suppress hepatitis B virus replication in primary hepatocytes. Clin. Immunol. Microbiol. Infect. In press. (Corresponding author) ^vSXdh‰W Of[Tukag Y TNSfNSLyYecgؚf[SZSXf[N{S1997-2001 -NVNl'Yf[~Nmf[f[X 2002-2005 e,gN'Yf[ uirDn~Nmf[UxX 2005-2009 V[Yl<\N]z'Yf[QN0sXT:SW~Nmf[NSNSf[SZSX ]\OUSMOSLR_VT^9h'Yf[T|e_econyu@googlemail.com;NxvzeTQN~Nmf[]\O~S2009 N_VT^9h'YRtYec Tenure-Track Junior Professor ;Nyxb1\1 Gao Z., L. House and X. Yu (2010):  Using Choice Experiment to Estimate Consumer Valuation: the Role of Experiment Design and Attribute Information Loads . Agricultural Economics, Vol. 41 (6) 555-565. 2 Yu X. and David Abler (2010):  Incorporating Zero and Missing Responses into CVM with Open-Ended Bidding: Willingness to Pay for Blue Skies in Beijing. Environment and Development Economics, Vol.15:535-556. 3 Yu X. and Zhifeng Gao(2010):  An Updated Ranking of the Economic Research Institutions in China (2000-2009)", China Economic Review, Vol. 21(4):571-581. 4Gao Z., T. Schroeder and X. Yu (2010).  Consumer Willingness-to-Pay for Cue Attribute: the Value beyond its Own. Journal of International Food and Agribusiness Marketing, Vol.22(1):108-124. 5 Yu X. and D. Abler: (2010)  Interactions between Cigarette and Alcohol Consumption in Rural China , European Journal of Health Economics. Vol. (11):151 160. 6Yu X. and D. Abler(2009): The Demand for Food Quality in Rural China. American Journal of Agricultural Economics, Vol. 91(1): 57-69. 7Yu X. and G. Zhao (2009): Chinese Agricultural Development in 30 Years: A Literature Review. Frontiers of Economics in China, Vol.4 (4):633-648. ^vSXd%{QlST6eeQNNel Nv Y TbSLyxvzXTgؚf[SZSXf[N{S2001t^2007t^ (WfkIl'Yf[_uirb/gNNf[Xf[MOTUxXf[MO 2007t^2010t^ (W_VylKQ`nfΐKQf[O N^\v iiryxvz@b_ZSXf[MO]\OUSMOSLR_VlKQ`-nfgKQxvz@by T|e_xunli@mpipz.mpg.de;NxvzeT iirf[]\O~S(Wlnf iiryxvz@bۏLZSXTxvz]\O;Nyxb1\(WZSXf[`Ng bS;NSNxvz iir!j_Ƌ+RSSON[vbu:gt0 iir!j_Ƌ+RSSON[vbu/f iirR~MQuv;N~bR [ g+RN iirbu'`ˆ}vN[vbu:gt0MR_w iirSO{_FO^1vbu\O(u T_w iirSO:_pFOUSNvMQu\O(u01uN[vbuS^{_ gNeg[[v\O(u:gtvxvzl gHNmeQ0FO/f1uN[v^1He^ iir!j_Ƌ+RSSON[vbu/f iirSO[ gHevbue_KNN0Ǐ[ iirzSSOvxvzSs iir!j_Ƌ+RSSOvTb(W iir~ހQS0RQ(Qˆ}vvc0 NNYdk iirbuǏ z-NvMQuS^Ǐ zNg~vbu\O(uv^l gvcvPޏsQ|0ُN͑'YSsN2009t^ShN 0 PNAS 0 0EMBO Journal 0 N0 Te bS؏SNN'Y}v|uuS̃ Blumeria graminis f.sp. hordei (Bgh) hQWV~vKm^N^RteT]\O0 iiruS̃vxvz/fxvz iirutv͑~bR V:N iirbu'`1u iirSOTuSSOSevN\O eg0['Y}v|uuS̃BghvxvzSs vQWV~ g'YϑR~N"T!k~N"WV:1Y cedksaN[NSX[;mN;mSO[;N Nvyr'`vsQ0ُ[NTvv^v iirbu'`vxvz]\O g͑'YaIN dkxvzbgN2010t^ShN 0Science 0 N0^vSXd iir!j_Ƌ+RSSON[vbu:gt Y T}vgLyxvzXTgؚf[SZSXf[N{S07/2004 03/2008 _VV((Mainz)'Yf[;Sf[|VRN~ހuir@bZSXu 10/2003 05/2004 _VLvuxvz-N_(DKFZ)ZPUxXkNe 05/2000 05/2004 _VHohenheim 'Yf[%{Qf[UxX 09/1990 07/1995-NV;Sy'Yf[;Sf[,gy]\OUSMOSLR_V_luir;SoTlQSlNT|e_lin.bai@yangtse-biotech.de;NxvzeTuir;So]\O~S2010N_V_luir;SoTlQS(Yangtse Biotech Consulting)lN 2008 2009_VU^<\ў(LMU Munich)'Yf[oir|ZSXTxvzXT0oiryf[,gyf[uut[RYe 2008_VNm]'Y(RWTH Aachen)RP[N~ހVR@b ZSXTxvzXT 2003_VHohenheim 'Yf[NW@xSf[[[XT 2001 2003 _VFraunhoferxvz@b(uirb/g@b IGB)yxRt 1995 1999 SNwmQ;`;Sb;S^ ;Nyxb1\ 1. Holger Bengs, Lin Bai. Biotechnologie in China: Ein Stimmungsbericht. Nachricht aus der Chemie. 58/Okt. 2010 2. Holger Bengs, Lin Bai. China auf dem Vormarsch. GoingPublic BIOTECHNOLOGIE 2010 :106-107 3. Holger Bengs, Lin Bai. China on the advance. GoingPublic BIOTECHNOLOGIE 2010. 4. Holger Bengs, Lin Bai. Chinas Wandel vom Generikahersteller zum Innovator im Gesundheitsmarkt. BIOspektrum. 05/2010:586-587 5. H. Bengs, L. Bai. Gute Stimmung in China. Chemiewirtschaft. 09/2010:910-911 6. Holger Bengs & Lin Bai. Aktueller Stimmungsbericht aus China. VentureCapital Magazin. 7-8/2010 7. Michalakis S, Mhlfriedel R, Tanimoto N, Krishnamoorthy V, Koch S, Fischer MD, Becirovic E, Bai L, Huber G, Beck SC, Fahl E, Bning H, Paquet-Durand F, Zong X, Gollisch T, Biel M, Seeliger MW. Mol. Ther. 2010 Dec; 18(12):2057-63 8. Bai L, Zimmer S, Rickes O, Rohleder N, Holthues H, Engel L, Leube RE, and Spessert R.Brain Res. 2008, 1203:89-96 9. Bai L, Spiwoks-Becker I, and Leube RE. 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Smith, K. R., Muir, J., Rao, Y., Haucke, V., and Kittler J. T., K, Stabilisation of GABAA receptors at endocytic zones is mediated by an AP2 binding motif within the GABAA receptor 3 subunit, 2011, submitted 2. Rao, Y. & Haucke, V., Membrane shaping by the Bin/amphiphysin/Rvs (BAR) domain protein superfamily. (2011), Cell Mol Life Sci, (Invite review) 3. Rao, Y., Ruckert, C., Saenger, W., and Haucke, V. The early steps of endocytosis: From cargo selection to membrane deformation. (2011) Eur J Cell Biol, In Press. 4. Rao, Y., Ma, Q., Vahedi-Faridi, A., Sundborger, A., Pechstein, A., Puchkov, D., Luo, L., Shupliakov, O., Saenger, W., and Haucke, V. (2010). Molecular basis for SH3 domain regulation of F-BAR-mediated membrane deformation. Proc Natl Acad Sci U S A 107, 8213-8218. 5. Rao, Y., Bian, C., Yuan, C., Li, Y., Chen, L., Ye, X., Huang, Z., and Huang, M. (2006). An open conformation of switch I revealed by Sar1-GDP crystal structure at low Mg2+. Biochem Biophys Res Commun 348, 908-915. 6. Rao, Y., Yuan, C., Bian, C., Hou, X., Li, Y., Zhao, G., Ye, X., Huang, Z., and Huang, M. (2006). Crystal Structure of Sar1[H79G]-GDP Which Provides Insight into the Coat-controlled GTP Hydrolysis in the Disassembly of COP II. 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