Title: Histone methylation Regulates the fate of spermatogonial stem cell

　　Time: 2:50 pm, October 21, 2019

　　Venue: S3119 

　　Introduction of Speaker:

　　Dr.Wenxian Zeng is a professor in the Department of Animal Sciences

　　College of Animal Sciences & Technology, Northwest A & F University. Dr. Zeng got his B.S. and M.S. from Sichuan Agricultural University in 1984 and 1987 respectively, and got his Ph.D from Hiroshima University, Japan in 2001. Dr. Zeng had his Post Doctoral Research training in Hiroshima University and Tulane University and University of Pennsylvania during 2001 and 2004. Dr. Zeng’s research focuses on the molecular regulation of spermatogonial stem cell (SSC) renewal and differentiation. SSC is at the foundation of spermatogenesis which provides sperm production throughout the lifetime of a male. Similar to other adult stem cells, SSC is a tissue-specific stem cell population which has the potential for self-renewal and production of differentiated daughter cells. SSC is unique in its capability to contribute genes to next generation making it a perfect target for genetic manipulations. Currently the mechanisms that regulate SSC renewal and differentiation in mammalian are poorly understood. His research goal is to identify SSC molecular markers, and the regulation mechanisms of SSC renewal. Dr. Zeng also studies preservation of male fertility. Artificial insemination (AI) in swine has attained widely acceptability throughout the world. However, boar sperm are extremely sensitive to cold shock and cryopreservation. The low survival and poor fertilizing capability limit the frozen boar semen from being widely applied in the industry. His lab has successfully developed a new technique for preservation of boar semen. In addition, preservation and transplantation of SSC and testis tissue is another project in our laboratory for conservation of valuable immature males especially for endangered species and superexcellent farm animals. Dr. Zeng has published his research results in top journals, such as Stem Cells, Cell Death and Disease,Journal of Hematology & Oncology, Endocrinology, Biology of Reproduction, The FASEB Journal, Reproduction and Theriogenology.