WU chunyan
WU Chunyan
Ph.D., Associate Professor；
Contact information
Address: College of Veterinary Medicine, Northwest A&F University
No. 22 Xinong Road, Yangling, 712100, Shaanxi, China.
Email: nanyuchen2015@nwafu.edu.cn,
1. Education and Work Experience
08.2015 – present, Associate Professor, College of Veterinary Medicine, Northwest A&F University, Yangling, China;
01.2014 – 07.2015, Postdoctoral training, College of Veterinary Medicine, University of Maryland College Park, the United States;
09.2009 – 01.2014, Ph.D., Ludwig Maximilian University of Munich, Germany;
09.2007 – 07.2009, Master of Science, College of Life Science, Northwest A&F University, Yangling, China;
09.2003 – 07.2007, Bachelor, bioengineering, College of Life Science, Northwest A&F University
2. Research and Teaching
Research interests:
Prevention, control and Viral-host Interaction of ASFV and PRRSV;
Novel vaccine development based on Immunopeptidome technology;
Teaching:
Veterinary Immunology, Immunobiology for bachelor students.
3. Memberships and Academic Services
Member of the American Society of Microbiology
4. Publications
2021
[1] Zhigang Zhang, Tianshu Zhai, Mingshuo Li, Kun Zhang, Jingrui Li, Xu Zheng, Chaonan Tian, Rui Chen, Jianhui Dong, En-Min Zhou*, Yuchen Nan * and Chunyan Wu*; A broadly neutralizing monoclonal antibody induces broad protection against heterogeneous PRRSV strains in piglets, Veterinary Research,
[2] Chengbo Zhu, Jingrui Li, Chaonan Tian, Mengmeng Qin, Zhenni Wang, Bingjun Shi, Guanggang Qu*, Chunyan Wu* and Yuchen Nan* ; Proteomic Analysis of ISGylation in Immortalized Porcine Alveolar Macrophage Cell Lines Induced by Type I Interferon, Vaccines,
[3] Xiaohui Ju#, Fang Li#, Jingrui Li#, Chunyan Wu#, Guangtao Xiang Xiaomin Zhao, Yuchen Nan* , Dongming Zhao * and Qiang Ding * ; Genome-wide transcriptomic analysis of highly virulent African swine fever virus infection reveals complex and unique virus host interaction, Veterinary Microbiology,
[4] Zhaobin Zhou, Yinqian Xie, Chunyan Wu*, and Yuchen Nan* ; The Hepatitis E Virus Open Reading Frame 2 Protein: Beyond Viral Capsid, Frontiers in Microbiology,
[5] Jie Wang, Yajing Wang, Bing Liu, Yunwei He, Zhiwei Li, Qin Zhao, Yuchen Nan* and Chunyan Wu*; Porcine epidemic diarrhea Virus envelope protein blocks SLA-DR expression in barrow-derived dendritic cells by inhibiting promoters activation, Frontiers in Immunology,
2020
[1] Chunyan Wu; Guoqian Gu, Tianshu Zhai, Yajing Wang Yongling Yang, Yafei Li, Xu Zheng, Qin Zhao; En-Min Zhou * and Yuchen Nan * and Broad neutralization activity against both PRRSV-1 and PRRSV-2 and enhancement of cell mediated immunity against PRRSV by a novel IgM monoclonal antibody, Antiviral Research;
[2] Chunyan Wu, Bingjun Shi, Di Yang, Kun Zhang, Jie Li, Jie Wang, Hongliang Liu, Qin Zhao, En-Min Zhou* and Yuchen Nan*; Porcine Reproductive and Respiratory Syndrome Virus promotes SLA-DR-mediated antigen presentation of non-structure proteins to evoke a non-neutralizing antibody response in vivo , Journal of Virology,
[3] Yafei Li, Junhui Li, Sun He, Wei Zhang, Jian Cao, Xiaomei Pan, Huifen Tang, En-Min Zhou *， Chunyan Wu* and Yuchen Nan*; Interferon Inducing Porcine Reproductive and Respiratory Syndrome Virus Vaccine Candidate Protected Piglets from HP-PRRSV Challenge and Evoke a Higher Level of Neutralizing Antibodies Response, Vaccines,
[4] Liangliang Li, Lu Zhang, Qifan Hu, Liang Zhao, Yuchen Nan, Gaopeng Hou, Yiyang Chen, Ximeng Han, Xiaolei Ren, Qin Zhao, Hu Tao, Zhenzhao Sun, Gaiping Zhang, Chunyan Wu*, Jingfei Wang*, En-Min Zhou* ： MYH9 Key Amino Acid Residues Identified by the Anti-Idiotypic Antibody to Porcine Reproductive and Respiratory Syndrome Virus Glycoprotein 5 Involve in the Virus Internalization by Porcine Alveolar Macrophages, Viruses;
2019
[1] Lizhen Wang, Lu Zhang, Baichen Huang, Kuokuo Li, Gaopeng Hou, Qin Zhao, Chunyan Wu , Yuchen Nan , Taofeng Du, Yang Mu, Jixun Lan, Hongying Chen and En-Min Zhoua*; A Nanobody Targeting Viral Non-Structural Protein 9 Inhibits Porcine Reproductive and Respiratory Syndrome Virus Replication, Journal of Virology;
[2] Gaopeng Hou, Biyun Xue, Liangliang Li, Yuchen Nan, Lu Zhang, Kuokuo Li, Qin Zhao, Julian Hiscox, James Stewart, Chunyan Wu*, Jingfei Wang* and En-Min Zhou*; Direct interaction between CD163 N-terminal domain and MYH9 C-terminal domain contributes to porcine reproductive and respiratory syndrome virus internalization by permissive cells, Frontiers in Microbiology;
[3] Jie Wang, Jie Li, Nana Wang, Qi Ji, Mingshuo Li, Yuchen Nan, En-Min Zhou, Yanjin Zhang and Chunyan Wu*; The 40 kDa Linear Polyethylenimine Inhibits Porcine Reproductive and Respiratory Syndrome Virus Infection by Blocking Its Attachment to Permissive Cells, Viruses;
[4] Biyun Xue, Gaopeng Hou, Guixi Zhang, Jingjing Huang, Liangliang Li, Yuchen Nan, Yang Mu, Lizhen Wang, Lu Zhang, Ximeng Han, Xiaolei Ren, Qin Zhao, Chunyan Wu* , Jingfei Wang * and En-Min Zhou * ; MYH9 Aggregation Induced by Direct Interaction with PRRSV GP5 Ectodomain Facilitates Viral Internalization by Permissive Cells, Frontiers in Microbiology;
2018年
[1] Yuchen Nan; Chunyan Wu* ; and Yan-Jin Zhang * ; Interferon Independent Non‐Canonical STAT Activation and Virus Induced Inflammation, Viruses;
[2] Liangliang Li; Biyun Xu; Weiyao Sun; Guoqian Gu; Gaopeng Hou; Lu Zhang; Chunyan Wu ; Qin Zhao; Yanjin Zhang; Gaiping Zhang; Julian A. Hiscox; Yuchen Nan * and En-Min Zhou * ; Recombinant MYH9 protein C-terminal domain blocks porcine reproductive and respiratory syndrome virus internalization by direct interaction with viral glycoprotein 5, Antiviral Research;
[3] Jie Li, Gang Wang, Di Yang, Bao Zhao, Yongpan Zhao, Yonggang Liu, Xuehui Cai, Yuchen Nan, En-Min Zhou* and Chunyan Wu, * ; Development of luciferase-linked antibody capture assay based on luciferase Immunoprecipitation systems for antibody detection of porcine reproductive and respiratory syndrome virus, BMC Biotechnology;
2017
[1] Yuchen Nan#, Chunyan Wu#, Guoqian Gu, Weirao Sun and En-Min Zhou; Improved Vaccine against PRRSV: Current progress and future perspective, Frontiers in Microbiology ;
[2]Yuchen Nan, Chunyan Wu , Qin Zhao and En-Min Zhou*； Zoonotic Hepatitis E Virus: An Ignored Risk for Public Health; Frontiers in Microbiology;
[3]Yuchen Nan, Chunyan Wu* and Yan-Jin Zhang*；Interplay between Janus Kinase/Signal Transducer and Activator of Transcription Signaling Activated by Type I Interferons and Viral Antagonism; Frontiers in Immunology;
2015
[1] Chunyan Wu , Yuchen Nan and Yan-Jin Zhang; New insights into virus–cell interactions during HEV infection: The double roles of HEV in IFNs induction; Future Virology; 2015;
2013
[1] Chunyan, Wu, M, Aichinger., J, Nedjic. and L, Klein. Thymic epithelial cells use macroautophagy to turn their inside out for CD4 T cell tolerance. Autophagy；
[2] M, Aichinger*, Chunyan, Wu*, J, Nedjic. and L, Klein. Macroautophagy substrates are loaded onto MHC Class II of medullary thymic epithelial cells for central tolerance. J. Exp. Med. 2013; 210 (2):287-300. (* Co-first author)
6. Projects and Funding
[1] General Project, No. 32170165, National Natural Science Foundation of China (NSFC), RMB 590,000, 2022 - 2025 grant holder.
[2] Development of ASFV subunit vaccine. Industrial service agreement, RMB 3 million, 2021 – 2025, lead researcher.
[3] Development of ASFV subunit vaccine. Industrial service agreement, RMB 3 million, 2021 – 2025, lead researcher.