ZHANG shiqiang
1. PERSONAL DATA
ZHANG Shiqiang, Ph. D., Associate Professor
Email: shiqiangzhang@nwsuaf.edu.cn
Address: No.3 Taicheng Road, Yangling, Shaanxi, China
Current Affiliation: Department of Basic Veterinary Medicine, College of Veterinary Medicine; Shaanxi Centre of Stem Cells Engineering & Technology.
2. EDUCATION
2015-2016, The University of British Columbia, Visiting Scholar
2007-2011, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Ph.D. in Cell Biology
2004-2007, Northwest A&F University, Master in Development Biology
2000-2004, Northwest A&F University, Bachelor in Animal Science
3. Professional experience
2011-2015, Lecturer, College of Veterinary Medicine, Northwest A&F University
2016-present, Associate Professor, College of Veterinary Medicine, Northwest A&F University
4. Research Interests
Induced pluripotent stem cells are important for potential applications in human regenerative medicine and veterinary medicine. However, the somatic reprogramming process is inefficient and the molecular mechanisms underlying somatic reprogramming are not fully understood. The long-term goal of ZHANG’s lab is to identify the epigenetic barriers during this process and understand the fundamental questions regarding cell plasticity, cell identity and cell fate decisions.
5. Publications
1. Zhu Z, Wu X, Li Q, Zhang J, Yu S, Shen Q, Zhou Z, Pan Q, Yue W, Qin D, Zhang Y, Zhao W, Zhang R, Peng S, Li N, Zhang S, Lei A, Miao YL, Liu Z, Chen X, Wang H, Liao M, Hua J. "Histone Demethylase Complexes Kdm3a and Kdm3b Cooperate with Oct4/Sox2 to Define a Pluripotency Gene Regulatory Network." FASEB J 35, no. 6 (2021): e21664.
2. Wu XL, Zhu ZS, Xiao X, Zhou Z, Yu S, Shen QY, Zhang JQ, Yue W, Zhang R, He X, Peng S, Zhang S, Li N, Liao MZ, Hua JL. "Lin28a Inhibits Dusp Family Phosphatases and Activates Mapk Signaling Pathway to Maintain Pluripotency in Porcine Induced Pluripotent Stem Cells." Zool Res 42, no. 3 (2021): 377-388.
3. Zhang M, Li N, Liu W, Du X, Wei Y, Yang D, Zhou Z, Ma F, Peng S, Zhang S, He X, Bai C, Li G, Hua J. "Eif2s3y Promotes the Proliferation of Spermatogonial Stem Cells by Activating Erk Signaling." Stem Cells Int, (2021): 6668658.
4. Zhu K, Liu Y, Fan C, Zhang M, Cao H, He X, Li N, Chu D, Li F, Zou M, Hua J, Wang H, Wang Y, Fan G, Zhang S. "Etv5 Safeguards Trophoblast Stem Cells Differentiation from Mouse EPSCs by Regulating Fibroblast Growth Factor Receptor 2." Mol Biol Rep 47, no. 12 (2020): 9259-9269.
5. Zhu Z, Pan Q, Zhao W, Wu X, Yu S, Shen Q, Zhang J, Yue W, Peng S, Li N, Zhang S, Lei A, Hua J. "Bcl2 Enhances Survival of Porcine Pluripotent Stem Cells through Promoting Fgfr2." Cell Prolif, (2020): e12932.
6. Liu W, Li N, Zhang M, Liu Y, Sun J, Zhang S, Peng S, Hua J. "Eif2s3y Regulates the Proliferation of Spermatogonial Stem Cells Via Wnt6/<Beta>-Catenin Signaling Pathway." Biochim Biophys Acta Mol Cell Res (2020): 118790.
7. Xie, Y., Cao, H., Zhang, Z., Zhang S. and Wang, H. (2019). Molecular network of miR-1343 regulates the pluripotency of porcine pluripotent stem cells via repressing OTX2 expression. RNA biology 16, 82-92.
8. Zhang J., Cao H; Xie J; Fan C; Xie Y, He X, Liao M, Zhang S*, Wang H*.(2018).The oncogene Etv5 promotes MET in somatic reprogramming and orchestrates epiblast/primitive endoderm specification during mESCs differentiation. , Cell Death & Disease, 9(2): 224.
9. Zhang S*, Xie Y, Cao H, Wang H*. (2017). Common microRNA-mRNA interactions exist among distinct porcine iPSC lines independent of their metastable pluripotent states. Cell Death & Disease 8, e3027.
10. Wei Y, Fang J, Cai S, Lv C, Zhang S, Hua J. (2016). Primordial germ cell-like cells derived from canine adipose mesenchymal stem cells. Cell Proliferation 49(4):503-511.
11. Zhang S, Guo Y, Cui Y, Liu Y, Yu T, Wang H. (2015). Generation of intermediate porcine iPS cells under culture condition favorable for mesenchymal-to-epithelial transition. Stem Cell Reviews and Reports 11(1):24-38.
12. Gao Y, Guo Y, Duan A, Cheng D, Zhang S, Wang H. (2014). Optimization of culture conditions for maintaining porcine induced pluripotent stem cells. DNA Cell Biology 33, 1-11.
13. Xu R, Zhang S, Lei A. (2014). Chromatin changes in reprogramming of mammalian somatic cells. Rejuvenation Research 17, 3-10.
14. Zhang S*, Teng Y*. (2013). Powering mammalian genetic screens with mouse haploid embryonic stem cells. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 741—742, 44-50.
15. Li W, Wang X, Fan W, Zhao P, Chan YC, Chen S, Zhang S, Guo X, Zhang Y, Li Y, Cai J, Qin D, Li X, Yang J, Peng T, Zychlinski D, Hoffmann D, Zhang R, Deng K, Ng KM, Menten B, Zhong M, Wu J, Li Z, Chen Y, Schambach A, Tse HF, Pei D, Esteban MA. (2012). Modeling abnormal early development with induced pluripotent stem cells from aneuploid syndromes. Human Molecular Genetics 21, 32-45.
16. Zhang S, Chen S, Li W, Guo X, Zhao P, Xu J, Chen Y, Pan Q, Liu X, Zychlinski D, Lu H, Tortorella MD, Schambach A, Wang Y, Pei D, Esteban MA. (2011). Rescue of ATP7B function in hepatocyte-like cells from Wilson's disease induced pluripotent stem cells using gene therapy or the chaperone drug curcumin. Human Molecular Genetics 20, 3176-3187.
17. Esteban MA, Wang T, Qin B, Yang J, Qin D, Cai J, Li W, Weng Z, Chen J, Ni S, Chen K, Li Y, Liu X, Xu J, Zhang S, Li F, He W, Labuda K, Song Y, Peterbauer A, Wolbank S, Redl H, Zhong M, Cai D, Zeng L, Pei D. (2010). Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell 6, 71-79.