Title: Prof. Liao, Mingzhi

Contact Information:

Mailing Address:

College of Life Sciences

Northwest A&F University

Yangling, Shaanxi 712100

P. R. China

Phone: (86) 29 87092262

Fax: (86) 2987092262

E-mail: liaomz@nwsuaf.edu.cn

Office: North Campus, Science Building, College of Life Sciences, E207

Research Interests:

The era of biological data explosion not only brings researchers new development opportunities, but also brings great challenges in data processing and analysis. To this end, our research team has carried out the information mining of multi-omics "biological big data", mainly using mathematics, computer and other theories and tools to carry out the research of computational system biology. Our research goal is to build professional database platforms, develop biological algorithm softwares, and mine the potential information behind biological big data (including text data, genome, transcriptome, proteome Epigenomes, exposure groups and their complex interaction processes), realize the transformation from "big data" to "big information", so as to discover new biological phenomena, new markers and new laws.

At present, we pay attention to the fronteirers interdisciplinary research directions of bioinformatics of animal reproductive development, including: (1) basic biological research: molecular mechanism of animal reproductive development, stem cell stem maintenance and differentiation mechanism; (2) Applied basic biology research: reproductive genetics, animal genome selection and breeding, etc; (3) Mathematical basis and Application Research: artificial intelligence algorithm and biological big data.

Education Experiences:

Harbin Medical University, Biophysics (major), Ph.D. 2011

Northwest University, Information and Computing Science (major), B. S. 2006

Professional Experiences:

Visiting Scholar in The University of California, San Diego (2017.09-2018.09)

Professor in College of Life Sciences & Center of Bioinformatics, Norwest A&F University (2021-present)

Associate Professor in College of Life Sciences & Center of Bioinformatics, Norwest A&F University (2015-2020)

Instructor in College of Life Sciences & Center of Bioinformatics, Norwest A&F University (2011-2014)

Publications:

In recent years, Prof. Liao has published more than 50 SCI papers, including papers published in bioinformatics journals such as Briefs in Bioinformatics, Bioinformatics, BMC bioinformatics,  Genomics and Gene, as well as papers published in the Journal of biological chemistry, Cell Death & Disease, Cell Cycle, Reproduction, Zoological research, The FASEB Journal and papers published in comprehensive journal, such as Advanced Science. Among them, there are 3 papers with IF > 10 with Prof. Liao as corresponding authors in recent 5 years, and the H-index with Prof. Liao currently is 23.

Attachment: list of papers published as corresponding authors in recent 5 years

1 Li, H., Hou, J., Chen, Z., Zeng, J., Ni, Y., Li, Y., Xiao, X., Zhou, Y., Zhang, N., Long, D., Liu, H., Yang, L., Bai, X., Li, Q., Li, T., Che, D., Li, L., Wang, X., Zhang, P. & Liao, M. FifBase: a comprehensive fertility-associated indicators factor database for domestic animals.  Briefings in Bioinformatics , 1-7, (2021).

2 Zhu, Z., Wu, X., Li, Q., Zhang, J., Yu, S., Shen, Q., Zhou, Z., Pan, Q., Yue, W., Qin, D., Zhang, Y., Zhao, W., Zhang, R., Peng, S., Li, N., Zhang, S., Lei, A., Miao, Y. L., Liu, Z., Chen, X., Wang, H., Liao, M. & Hua, J. Histone demethylase complexes KDM3A and KDM3B cooperate with OCT4/SOX2 to define a pluripotency gene regulatory network.  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 35, e21664, (2021).

3 Yu, X. W., Li, T. T., Du, X. M., Shen, Q. Y., Zhang, M. F., Wei, Y. D., Yang, D. H., Xu, W. J., Chen, W. B., Bai, C. L., Li, X. L., Li, G. P., Li, N., Peng, S., Liao, M. Z. & Hua, J. L. Single-cell RNA sequencing reveals atlas of dairy goat testis cells.  Zoological   R  esearch 42, 401-405, (2021).

4 Wu, X. L., Zhu, Z. S., Xiao, X., Zhou, Z., Yu, S., Shen, Q. Y., Zhang, J. Q., Yue, W., Zhang, R., He, X., Peng, S., Zhang, S. Q., Li, N., Liao, M. Z. & Hua, J. L. LIN28A inhibits DUSP family phosphatases and activates MAPK signaling pathway to maintain pluripotency in porcine induced pluripotent stem cells.  Zoological   R  esearch 42, 377-388, (2021).

5 Sun, C., Zhang, N., Yu, P., Wu, X., Li, Q., Li, T., Li, H., Xiao, X., Shalmani, A., Li, L., Che, D., Wang, X., Zhang, P., Chen, Z., Liu, T., Zhao, J., Hua, J. & Liao, M. Enhancer recognition and prediction during spermatogenesis based on deep convolutional neural networks.  Mol Omics 16, 455-464, (2020).

6 Shen, Q., Xiao, X., Aierken, A., Yue, W., Wu, X., Liao, M. & Hua, J. The ACE2 expression in Sertoli cells and germ cells may cause male reproductive disorder after SARS-CoV-2 infection.  Journal of   C  ellular and   M  olecular   M  edicine 24, 9472-9477, (2020).

7 Li, T., Li, Q., Li, H., Xiao, X., Warraich, D. A., Zhang, N., Chen, Z., Hou, J., Liu, T., Weng, X., Liu, Z., Hua, J. & Liao, M. Pig-specific RNA editing during early embryo development revealed by genome-wide comparisons.  Febs Open Bio 10, 1389-1402, (2020).

8 Li, Q., Li, T., Xiao, X., Ahmad, D. W., Zhang, N., Li, H., Chen, Z., Hou, J. & Liao, M. Specific expression and alternative splicing of mouse genes during spermatogenesis.  Molecular Omics 16, 258-267, (2020).

9 Wang, X., Wu, X., Zhu, Z., Li, H., Li, T., Li, Q., Zhang, P., Li, L., Che, D., Xiao, X., Liu, T., Hua, J. & Liao, M. Landscape of RNA editing reveals new insights into the dynamic gene regulation of spermatogenesis.  Cell Cycle 18, 3351-3364, (2019).

10 Li, L., Che, D., Wang, X., Zhang, P., Rahman, S. U., Zhao, J., Yu, J., Tao, S., Lu, H. & Liao, M. CellSim: a novel software to calculate cell similarity and identify their co-regulation networks.  B  MC   Bioinformatics 20, 9, (2019).

11 Wang, X., Zhang, P., Li, L., Che, D., Li, T., Li, H., Li, Q., Jia, H., Tao, S., Hua, J., Zeng, W. & Liao, M. miRNA editing landscape reveals miR-34c regulated spermatogenesis through structure and target change in pig and mouse.  Biochemical And Biophysical Research Communications 502, 486-492, (2018).

12 Wang, W., Zhang, P., Li, L., Chen, Z., Bai, W., Liu, G., Zhang, L., Jia, H., Li, L., Yu, Y. & Liao, M. ATD: a comprehensive bioinformatics resource for deciphering the association of autophagy and diseases.  Database-the Journal Of Biological Databases And Curation , 10, (2018).

13 Che, D., Wang, Y., Bai, W., Li, L., Liu, G., Zhang, L., Zuo, Y., Tao, S., Hua, J. & Liao, M. Dynamic and modular gene regulatory networks drive the development of gametogenesis.  Briefings In Bioinformatics 18, 712-721, (2017).

14 Bai, W., Yang, W., Wang, W., Wang, Y., Liu, C., Jiang, Q., Hua, J. & Liao, M. GED: a manually curated comprehensive resource for epigenetic modification of gametogenesis.  Briefings In Bioinformatics 18, 98-104, (2017).