Prof.  Shen, Xihui

CONTACT INFORMATION:

College of Life Sciences,

Northwest A&F University,

Yangling, Shaanxi 712100, China

Phone: 86-29-87092820

Email: xihuishen@nwsuaf.edu.cn

Office: North Campus, Science Building, College of Life Sciences, D304

RESEARCH INTERESTS:

1. Microbe-plant interaction;

2. Microbial gene regulation;

3. Bacterial stress responses;

4. Bioremediation.

EDUCATION BACKGROUND:

Institute of Microbiology, Chinese Academy of Sciences, Microbiology, Ph.D. 2005

Northwest A&F University, Biochemistry, 1997

Northwest A&F University, Agronomy, 1994

PROFESSIONAL EXPERIENCES:

Professor in College of Life Science, Norwest A&F University (2010-present)

Associate Professor in Wuhan Institute of Virology, CAS, (2008-2010)

Postdoc in Purdue University, Department of Life Sciences (2005-2008)

Assistant Professor in Hubei Bt Research and Development Center (1997-2001)

HONORS AND AWARDS:

Distinguished Young Scholar, NSFC (2017)

Selected publications:

1. Li C^#, Zhu L^#, Wang D^#, Wei Z, Hao X, Wang Z, Li T, Zhang L, Lu Z, Long M, Wang Y*, Wei G*, Shen X*. T6SS secretes an LPS-binding effector to recruit OMVs for exploitative competition and horizontal gene transfer. ISME J, 2022; 16(2):500-510.

2. Zhu L^#, Xu L^#, Wang C^#, Li C, Li M, Liu Q, Wang X, Yang W, Pan D, Hu L, Yang Y, Lu Z, Wang Y, Zhou D*, Jiang Z*, Shen X*. T6SS translocates a micropeptide to suppress STING-mediated innate immunity by sequestering manganese. Proc Natl Acad Sci U S A. 2021;118(42):e2103526118.

3. Song L^#, Pan J^#, Yang Y^#, Zhang Z, Cui R, Jia S, Wang Z, Yang C, Xu L, Dong TG, Wang Y*, Shen X*. Contact-independent killing mediated by a T6SS effector with intrinsic cell-entry properties. Nat. Commun., 2021, 12(1):423. (Editor’s Highlights)

4. Zhang L^#*, Li S^#, Liu X, Wang Z, Jiang M, Wang R, Xie L, Liu Q, Xie X, Shang D, Li M, Wei Z, Wang Y, Fan C, Luo ZQ*, Shen X*. Sensing of autoinducer-2 by functionally distinct receptors in prokaryotes. Nat. Commun., 2020, 11(1):5371. (Editor’s Highlights)

5. Zhang L^#, Zhang W^#, Li Q, Cui R, Wang Z, Wang Y, Zhang YZ, Ding W*, Shen X*. Deciphering the root endosphere microbiome of the desert plant  Alhagi sparsifolia  for drought resistance-promoting bacteria. Appl. Environ. Microbiol., 2020, 86(11):e02863-19.

6. Wang Z^#, Wang T^#, Cui R, Zhang Z, Chen K, Li M, Hua Y, Gu H, Xu L, Wang Y, Yang Y*, Shen X*. HpaR, the Repressor of Aromatic Compound Metabolism, Positively Regulates the Expression of T6SS4 to Resist Oxidative Stress in  Yersinia pseudotuberculosis . Front. Microbiol., 2020, 11:705.

7. Zhang L^#*, Li M^#, Li Q, Chen C, Qu M, Li M, Wang Y, Shen X*. The catabolite repressor/activator, Cra, bridges a connection between carbon metabolism and host colonization in the plant drought resistance-promoting bacterium  Pantoea alhagi  LTYR-11Z. Appl. Environ. Microbiol., 2018. 84(13):e00054-18. (Spotlight article)

8. Lin J, Cheng J, Wang Y, Shen X*. The Pseudomonas Quinolone Signal (PQS): Not Just for Quorum Sensing Anymore. Front. Cell Infect. Microbiol., 2018, 8:230.

9. Jinshui Lin^#, Weipeng Zhang^#, Juanli Cheng, Xu Yang, Kaixiang Zhu, Yao Wang, Gehong Wei, Pei-Yuan Qian, Zhao-Qing Luo and Xihui Shen*. A  Pseudomonas  T6SS effector recruits PQS-containing outer membrane vesicles for iron acquisition. Nat. Commun., 2017, 8:14888

10. Meiru Si, Chao Zhao, Brianne Burkinshaw, Bing Zhang, Dawei Wei, Yao Wang, Tao G. Dong* and Xihui Shen*. Manganese scavenging and oxidative stress response mediated by the type VI secretion system in  Burkholderia thailandensis. PNAS, 2017, 114(11):E2233-E2242. (cited by Faculty of 1000 Prime)

11. Si M^#, Wang Y^#, Zhang B, Zhao C, Kang Y, Bai H, Wei D, Zhu L, Zhang L, Dong TG, Shen X*. A type VI secretion system engages a redox-regulated dual functional heme transporter for zinc acquisition. Cell Rep. 2017, 20:949-959

12. Si M, Wang T, Pan J, Lin J, Chen C, Wei Y, Lu Z, Wei G, Shen X*. Graded response of the multifunctional 2-Cys peroxiredoxin CgPrx to increasing levels of hydrogen peroxide in  Corynebacterium glutamicum . Antioxid Redox Signal., 2017, 26(1):1-14.

13. Tietao Wang^#, Mei-Ru Si^#, Yunhong Song^#, Yao Wang, Fen Gao, Weipeng Zhang, Lei Zhang, Gehong Wei, Zhao-Qing Luo, Xihui Shen*. Type VI secretion system transports Zn²⁺ to combat multiple stresses and host immunity. PLoS Pathog., 2015,11(7):e1005020.

14. Yunhong Song, Xiao Xiao, Changfu Li, Tietao Wang, Ruoxi Zhao, Weipeng Zhang, Lei Zhang, Yao Wang and Xihui Shen*. The dual transcriptional regulator RovM regulates the expression of AR3- and T6SS4-dependent acid survival systems in response to nutritional status in  Yersinia pseudotuberculosis.  Environ. Microbiol., 2015,17(11):4631-45.

15. Jinshui Lin, Juanli Cheng, Keqi Chen, Chenghao Guo, Weipeng Zhang, Xu Yang, Wei Ding, Li Ma, Yao Wang and Xihui Shen*. The  icmF3  locus is involved in multiple adaptation- and virulence-related characteristics in  Pseudomonas aeruginosa  PAO1. Front. Cell. Infect. Microbiol., 2015,5:70.

16. Boyu Cui^#, Yao Wang^#, Yunhong Song, Tietao Wang, Changfu Li, Yahong Wei, Zhao-Qing Luo* and Xihui Shen*. A bioluminescence resonance energy transfer (BRET) system for measuring dynamic protein-protein interactions in bacteria. mBio, 2014, 20;5(3):e01050-14

17. Shengjuan Xu^#, Zhong Peng^#, Boyu Cui, Tietao Wang, Yunhong Song, Lei Zhang, Gehong Wei, Yao Wang* and Xihui Shen*.  FliS modulates FlgM activity by acting as a noncanonical chaperone to control late flagellar gene expression, motility and biofilm formation in Yersinia pseudotuberculosis. Environ. Microbiol., 2014, 16(4):1090-104 (cited by Faculty of 1000 Prime)

18. Weipeng Zhang, Yao Wang, Yunhong Song, Tietao Wang, Shengjuan Xu, Zhong Peng, Xiaoli Lin, Lei Zhang, Xihui Shen*. A type VI secretion system regulated by OmpR in  Yersinia pseudotuberculosis  functions to maintain intracellular pH homeostasis. Environ. Microbiol., 2013, 15(2):557-69.

19. Meiru Si, Yixiang Xu, Tietao Wang, Mingxiu Long, Wei Ding, Can Chen, Xinmeng Guan, Yingbao Liu, Yao Wang, Xihui Shen* and Shuang-Jiang Liu. Functional characterization of a mycothiol peroxidase in  C  orynebacterium   glutamicum  that uses both mycoredoxin and thioredoxin reducing systems as proton donor for oxidative stress response. Biochem. J. 2015, 469(1):45-57.

20. Meiru Si, Lei Zhang, Muhammad Tausif Chaudhry, Yixiang Xu, Can Chen, Wei Ding, Ali Akbar, Xihui Shen* and Shuang-Jiang Liu.  Corynebacterium glutamicum  methionine sulfoxide reductase (MsrA) uses both mycoredoxin and thioredoxin for regeneration and oxidative stress resistance. Appl. Environ. Microbiol. 2015, 81(8):2781-2796.