Israel Ausin

 Israel Ausin （以色列 奥辛）

Israel Ausin （以色列.奥辛）

教授，博士生导师 

生命科学学院    生物学

通讯地址： 南校区3号教学楼西面3216实验室

Email：israel.ausin@nwafu.edu.cn

一、个人简介
      
      Israel Ausin，男，1974年7月出生于西班牙马德里。2004年在马德里自治大学获得植物学博士学位，2005年加入美国加州大学洛杉矶分校Steven E. Jacobsen教授（美国科学院院士， HHMI研究员）实验室进行博士后研究。2011年博士后出站后任职西班牙国家生物技术研究中心(CNB-CSIC)的研究员，2014年入职福建农林大学。2019年12月入职 生命科学学院，任教授、博士生导师、植物染色质生物学课题组组长。

二、 研究方向

本课题组主要以模式植物拟南芥为研究材料，以组蛋白伴侣蛋白和组蛋白变体两类蛋白为出发点，综合运用分子生物学、生物化学、遗传学和各种组学的方法研究染色质结构变化与基因表达调控的分子机制。

三、主持的科研项目

（2）国家自然科学基金面上项目，31870270，核小体装配和沉积的新方案， 2019/01-2022/12, 60万，在研，主持；

（1）国家自然科学基金面上项目，31571328，泛素化修饰对小分子RNA介导的DNA甲基化影响的研究， 2016/01-2019/12, 65万，已结题，主持。

四、 发表的文章

      (*) = 共同第一或共同通讯作者

20. Arabidopsis SWR1-associated protein methyl-CpG-binding domain 9 is required for histone H2A.Z deposition. Potok ME, Wang Y, Xu L, Zhong Z, Liu W, Feng S, Naranbaatar B, Rayatpisheh S, Wang Z, Wohlschlegel JA, Ausin I(*), Jacobsen SE(*).  Nat Commun . 2019 Jul 26;10(1):3352. doi: 10.1038/s41467-019-11291-w.

19. Genetic interaction and molecular evolution of the duplicated genes ICARUS2 and ICARUS1 confer growth adaptation to ambient temperature in Arabidopsis. Mendez-Vigo B(*), Ausin I(*), Zhu W, Mollá-Morales A, Balasubramanian S, Alonso-Blanco C.  Plant Cell . 2019 June; (31)1222-37 doi:10.1105/tpc.18.00938.

18. Large-scale comparative epigenomics reveals hierarchical regulation of non-CG methylation in  Arabidopsis . Zhang Y, Harris CJ, Liu Q, Liu W, Ausin I, Long Y, Xiao L, Feng L, Chen X, Xie Y, Chen X,Zhan L, Feng S, Li JJ, Wang H, Zhai J, Jacobsen SE.  PNAS . 2018 Jan 30;115(5):E1069-E1074.

17. DNA methylome of the 20-gigabase Norway spruce genome. Ausin I, Feng S, Yu C, Liu W, Kuo HY,Jacobsen EL, Zhai J, Gallego-Bartolome J, Wang L, Egertsdotter U, Street NR, Jacobsen SE, Wang H. PNAS . 2016 Dec 13;113(50):E8106-E8113.

16. CG gene body DNA methylation changes and evolution of duplicated genes in cassava. Wang H,Beyene G, Zhai J, Feng S, Fahlgren N, Taylor NJ, Bart R, Carrington JC, Jacobsen SE, Ausin I.  PNAS .2015 Nov 3;112(44):13729-34.

15. A One Precursor One siRNA Model for Pol IV-Dependent siRNA Biogenesis. Zhai J, Bischof S, Wang H, Feng S, Lee TF, Teng C, Chen X, Park SY, Liu L, Gallego-Bartolome J, Liu W, Henderson IR, Meyers BC, Ausin I(*), Jacobsen SE(*).  Cell . 2015 Oct 8;163(2):445-55.

14. FE, a phloem-specific Myb-related protein, promotes flowering through transcriptional activation of FLOWERING LOCUS T and FLOWERING LOCUS T INTERACTING PROTEIN 1. Abe M, Kaya H,Watanabe-Taneda A, Shibuta M, Yamaguchi A, Sakamoto T, Kurata T, Ausin I, Araki T, Alonso-Blanco C. Plant J . 2015 Sep;83(6):1059-68.

13. Environmental and genetic interactions reveal FLOWERING LOCUS C as a modulator of the natural variation for the plasticity of flowering in Arabidopsis. Méndez-Vigo B, Savic M, Ausin I, Ramiro M, Martín B, Picó FX, Alonso-Blanco C.  Plant Cell Environ . 2016 Feb;39(2):282-94.

12. Natural Variation Identifies ICARUS1, a Universal Gene Required for Cell Proliferation and Growth at High Temperatures in Arabidopsis thaliana. Zhu W(*), Ausin I(*), Seleznev A, Méndez-Vigo B, Picó FX, Sureshkumar S, Sundaramoorthi V, Bulach D, Powell D, Seemann T, Alonso-Blanco C, Balasubramanian S.  PLoS Genet . 2015 May 7;11(5):e1005085.

11. Domains rearranged methyltransferase3 controls DNA methylation and regulates RNA polymerase V transcript abundance in Arabidopsis. Zhong X, Hale CJ, Nguyen M, Ausin I, Groth M, Hetzel J, Vashisht AA, Henderson IR, Wohlschlegel JA, Jacobsen SE.  PNAS . 2015 Jan 20;112(3):911-6.

10. SNF2 chromatin remodeler-family proteins FRG1 and -2 are required for RNA-directed DNA methylation. Groth M, Stroud H, Feng S, Greenberg MV, Vashisht AA, Wohlschlegel JA, Jacobsen SE, Ausin I.  PNAS . 2014 Dec 9;111(49):17666-71.

9. The TRANSPLANTA collection of Arabidopsis lines: a resource for functional analysis of transcription factors based on their conditional overexpression. Coego A, Brizuela E, Castillejo P, Ruíz S, Koncz C, del Pozo JC, Piñeiro M, Jarillo JA, Paz-Ares J, León J; TRANSPLANTA Consortium.  Plant J . 2014 Mar;77(6):944-53.

8. INVOLVED IN DE NOVO 2-containing complex involved in RNA-directed DNA methylation in Arabidopsis. Ausin I, Greenberg MV, Simanshu DK, Hale CJ, Vashisht AA, Simon SA, Lee TF, Feng S,Española SD, Meyers BC, Wohlschlegel JA, Patel DJ, Jacobsen SE.  PNAS . 2012 May 29;109(22):8374-81.

7. The splicing factor SR45 affects the RNA-directed DNA methylation pathway in Arabidopsis. Ausin I, Greenberg MV, Li CF, Jacobsen SE.  Epigenetics . 2012 Jan 1;7(1):29-33.

6. Identification of genes required for de novo DNA methylation in Arabidopsis. Greenberg MV, Ausin I,Chan SW, Cokus SJ, Cuperus JT, Feng S, Law JA, Chu C, Pellegrini M, Carrington JC, Jacobsen SE.  Epigenetics . 2011 Mar;6(3):344-54. Epub 2011 Mar 1.

5. Involvement of a Jumonji-C domain-containing histone demethylase in DRM2-mediated maintenance of DNA methylation. Deleris A, Greenberg MV, Ausin I, Law RW, Moissiard G, Schubert D, Jacobsen SE.  EMBO Rep . 2010 Dec;11(12):950-5.

4. A protein complex required for polymerase V transcripts and RNA- directed DNA methylation in Arabidopsis. Law JA, Ausin I, Johnson LM, Vashisht AA, Zhu JK, Wohlschlegel JA, Jacobsen SE.  Curr Biol . 2010 May 25;20(10):951-6.

3. IDN1 and IDN2 are required for de novo DNA methylation in Arabidopsis thaliana. Ausin I, Mockler TC,Chory J, Jacobsen SE.  Nat Struct Mol Biol . 2009 Dec;16(12):1325-7. doi: 10.1038/nsmb.1690. Epub2009 Nov 15.

2. Environmental regulation of flowering. Ausin I, Alonso-Blanco C, Martínez-Zapater JM.  Int J Dev Biol .2005;49(5-6):689-705.

1. Regulation of flowering time by FVE, a retinoblastoma-associated protein. Ausin I, Alonso-Blanco C,Jarillo JA, Ruiz-García L, Martínez-Zapater JM.  Nat Genet . 2004 Feb;36(2):162-6.