报告题目：Inference of genetic regulatory networks

　　报 告 人：吴方向 博士 （加拿大萨斯喀其温大学生医学物工程系教授）

　　报告时间：2011年6月7日 下午16:30

　　报告地点：生命学院四层多媒体室

　　报告内容及报告人介绍：
 
　　Abstract
　　Many diseases are genomic-alerted, such as obesity, cancer, HIV, swine flu (H1N1), etc. It is believed than genomic-alerted diseases stem from the malfunction of molecular biological systems, not only from isolated components. Systems biology aims at understanding biological systems at the systems-level and ultimately intervening the state of a system to desired state by drug and genetic engineering. During last decade, several advanced techniques such as DNA microarray, ChIP-on-chip, mass spectrometry have been developed to measure functional states and interactions of biological networks. With these large-scale biological data, especially time course gene expression data, a number of methods have been proposed to infer genetic regulatory network.

　　After reviewing the commonly used model, In this presentation I will introduce the methods that my group has recently developed for inferring genetic regulatory networks, which include methods for  inferring stable  and sparse linear genetic regulatory network, S-system model-based linear genetic regulatory network, and genetic regulatory networks with SUM logic.

　　Fang-Xiang Wu received the B. Sc. degree and the M. Sc. degree in Applied Mathematics, both from Dalian University of Technology, Dalian, China, in 1990 and 1993, respectively, the first Ph.D. in Control Theory and Its Applications from Northwestern Polytechnical University, Xi’an, China, in 1998, and the second Ph.D. in Biomedical Engineering from University of Saskatchewan (U of S), Saskatoon, Canada, in 2004. During 2004-2005, he worked as a postdoctoral fellow in the Laval University Medical Research Center (CHUL), Quebec City, Canada.
Dr. Wu has joined U of S since August 2005 and is currently an associate professor with tenure and the Graduate Chair of the Division of Biomedical Engineering at the U of S. His current research interests include computational and systems biology, genomic and proteomic data analysis, biological system identification and parameter estimation, applications of control theory to biological systems. Dr. Wu has published about 70 refereed journal papers and 60 refereed conference papers. Dr. Wu is serving as the editorial board member of two international journals, as the guest editor of several international journals, and as the program committee chair or member of several international conferences. He has also reviewed papers for many international journal.

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